Structural basis for the inhibition of translation through eIF2α phosphorylation

oleh: Yuliya Gordiyenko, José Luis Llácer, V. Ramakrishnan

Format: Article
Diterbitkan: Nature Portfolio 2019-06-01

Deskripsi

During stress, protein synthesis is inhibited through phosphorylation of the initiation factor eIF2 on its alpha subunit and its interaction with eIF2B. Here the authors describe a structure of the yeast eIF2B in complex with its substrate - the GDP-bound phosphorylated eIF2, providing insights into how phosphorylation results in a tighter interaction with eIF2B.