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Structural basis for the inhibition of translation through eIF2α phosphorylation
oleh: Yuliya Gordiyenko, José Luis Llácer, V. Ramakrishnan
Format: | Article |
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Diterbitkan: | Nature Portfolio 2019-06-01 |
Deskripsi
During stress, protein synthesis is inhibited through phosphorylation of the initiation factor eIF2 on its alpha subunit and its interaction with eIF2B. Here the authors describe a structure of the yeast eIF2B in complex with its substrate - the GDP-bound phosphorylated eIF2, providing insights into how phosphorylation results in a tighter interaction with eIF2B.