Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice
oleh: Gabriel L. Galea, Eirini Maniou, Timothy J. Edwards, Abigail R. Marshall, Ioakeim Ampartzidis, Nicholas D. E. Greene, Andrew J. Copp
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-02-01 |
Deskripsi
Mutations that cause tissue mosaicism have been identified in individuals with severe congenital defects. Here, the authors show that mosaic deletion of Vangl2 in the murine neuroepithlium causes spina bifida by preventing apical constriction via reduced myosin II and tubulin organisation.