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Background and Objective: Due to the widespread impact of diabetes on various aspects of life and the important role of self-efficacy in self-care behaviors of diabetic patients, we aimed at determining the relationship between quality of life dimensions and self-efficacy, and some related factors in patients with type 2 diabetes. Material and Methods: This cross-sectional study was conducted on 156 patients, selected via convenience sampling, with type II diabetes in Shroud (2013). The instruments were a demographic checklist, diabetic quality of life questionnaire and self-efficacy questionnaire. Data analysis was performed by descriptive statistics and Pearson correlation coefficient (0.05). Results: in accordance with the results, the quality of life was moderate and the lowest score was related to physical dimension. There was a significant relationship between self-efficacy and all aspects of quality of life in that the patients with higher self-efficacy had the more quality of life. Moreover, there was a significant linear relationship between quality of life and variables such as age, diabetes duration and body mass index. Conclusion: given that the increased self-efficacy is associated with quality of life improvement , it seems likely that we can maximize the quality of life in these patients by applying self-efficacy enhancement programs.