The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma
oleh: Alexander Vdovin, Tomas Jelinek, David Zihala, Tereza Sevcikova, Michal Durech, Hana Sahinbegovic, Renata Snaurova, Dhwani Radhakrishnan, Marcello Turi, Zuzana Chyra, Tereza Popkova, Ondrej Venglar, Matous Hrdinka, Roman Hajek, Michal Simicek
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Development of proteasome inhibitor resistance is a common problem in patients with multiple myeloma. Here, the authors show that deubiquitinase OTUD1 protects PRDX4 from degradation resulting in increased load of misfolded immunoglobulins sensitizing myeloma cells for proteasome inhibition.