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The saphenous nerve, a purely sensory branch of the femoral nerve, supplies the lower limb’s medial, anteromedial and posteromedial aspects from the thigh to the foot. It is generally blocked for anaesthesia during knee, ankle and foot surgeries and to relieve post-operative pain. Knee osteoarthritis is a common joint disorder in middle-aged and older adults with pain, articular stiffness and decreased physical activity. Pain owing to osteoarthritis is most often reported at the anteromedial aspect of the knee. Recently, many researchers have studied using ultrasound-guided saphenous nerve blocks in knee osteoarthritis to relieve pain. For knee pain relief, a saphenous nerve block can be done using one of the techniques, namely peri-femoral, sub-sartorial, trans-sartorial and para-condylar (at the medial femoral condyle). We briefly describe these here, mentioning the pre-requisites, contraindications, possible complications and clinical significance.