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The goal of the authors is adroit integration of three mainstream disciplines of the natural sciences, physics, chemistry and biology to create novel problem solving paradigms. This paper presents a brief history of the develop­ment of the natural sciences and highlights some milestones which subsequently influenced many branches of science, engineering and computing as a prelude to nature-inspired computing which has captured the imagination of computing researchers in the past three decades. The idea is to summarize the massive body of knowledge in a single paper suc­cinctly. The paper is organised into three main sections: developments in physics, developments in chemistry, and de­velopments in biology. Examples of recently-proposed computing approaches inspired by the three branches of natural sciences are provided.