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The existence and uniqueness of square-mean almost automorphic mild solution to a stochastic functional integrodifferential equation is studied. Under some appropriate assumptions, the existence and uniqueness of square-mean almost automorphic mild solution is obtained by Banach’s fixed point theorem. Particularly, based on Schauder’s fixed point theorem, the existence of square-mean almost automorphic mild solution is obtained by using the condition which is weaker than Lipschitz conditions. Finally, an example illustrating our main result is given.