CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities
oleh: Tomasz Ahrends, Julia Busselaar, Tesa M. Severson, Nikolina Bąbała, Evert de Vries, Astrid Bovens, Lodewyk Wessels, Fred van Leeuwen, Jannie Borst
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-12-01 |
Deskripsi
Help from CD4+ T cells is important to induce CD8+ T cell memory responses, but mechanistic insights are lacking. Here, the authors show, by transcriptomics and epigenetics, how CD4+ T cells help program memory CD8+ T cells for help-independent recall by antigens, as well as for innate-like recall responses by IL-12/IL-18 and promoting survival by IL-15.