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Trans humanist/post humanist sexuality is interpreted in two ways: as an expression of sexual fatigue and as shifts marked by marginal sexualities and fetish prostheses. This paper shows, from a bioethical approach and bio politics, that a triangular structure can be distinguished: the sexually tired subject, in which operate different strains expressed as sexual dysfunction, depression and monotony. The sexual hybrid in which the machine organism integration is produced under which operate all technoscientific interventions, which by way of prosthesis are inserted in a sexual functionality. Finally, sexual assembly is referred to as the modification of the environment based on their use for erotic purposes.