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Introduction: Globally, hysterectomy is the most common major gynecological procedure. Patients opting for hysterectomy for benign non-prolapse cases may be offered non-descent vaginal hysterectomy with quicker recovery, shorter hospital stay, and less intra- and post-operative morbidity compared to the abdominal route. Vaginal approach for hysterectomy is desirable in Nepal due to limited health resources. This study aimed to evaluate the intra- and post-operative complications of non-descent vaginal hysterectomy (NDVH). Methods: A prospective study was conducted at College of Medical Sciences over one-year period. A total of 50 cases were selected for NDVH on the basis of inclusion and exclusion criteria. Data regarding age, parity, uterine size, estimated blood loss, length of operation, complication and hospital stay were recorded. Results: The majority of women were in the age group of 41-45 years (mean age: 44.7±5.6 years) and multiparous (38%). The common indications for NDVH were fibroid uterus (66%) and adenomyosis (14%). The mean volume of blood loss was 121.5ml±110.94 and 3% required blood transfusion. The mean drop in hemoglobin level was statistically significant post surgery [1.05gm/dl]. The mean surgical time was 69.54±19.32 minutes. In the post-operative period, 10% women had UTI and 2% had fever. The mean duration of hospital stay was 4.06±0.24 days. Conclusion: Non-descent vaginal hysterectomy is a major surgery suitable in low-and middle income countries like Nepal with good outcomes and low complication rates.