High-pressure crystallography shows noble gas intervention into protein-lipid interaction and suggests a model for anaesthetic action
oleh: Igor Melnikov, Philipp Orekhov, Maksim Rulev, Kirill Kovalev, Roman Astashkin, Dmitriy Bratanov, Yury Ryzhykau, Taras Balandin, Sergei Bukhdruker, Ivan Okhrimenko, Valentin Borshchevskiy, Gleb Bourenkov, Christoph Mueller-Dieckmann, Peter van der Linden, Philippe Carpentier, Gordon Leonard, Valentin Gordeliy, Alexander Popov
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
Noble gases are known to interact with proteins and can be good anaesthetics in hyperbaric conditions. This study identifies argon and krypton binding sites on membrane proteins and proposes as a hypothesis that noble gases, by altering protein/lipid contacts, may affect protein function.