Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
oleh: Adriana Adolfi, Valentino M. Gantz, Nijole Jasinskiene, Hsu-Feng Lee, Kristy Hwang, Gerard Terradas, Emily A. Bulger, Arunachalam Ramaiah, Jared B. Bennett, J. J. Emerson, John M. Marshall, Ethan Bier, Anthony A. James
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-11-01 |
Deskripsi
Gene drives may be impeded by the generation of resistant alleles following NHEJ. Here the authors develop a recoded gene-drive rescue system for the malaria mosquito, Anopheles stephensi, that targets the drive to the kynurenine hydroxylase gene for negative selection against mutated alleles.