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The current studies were focused on the phytochemical profiling of two local wild <i>Artemisia</i> species, <i>Artemisia scoparia</i> and <i>Artemisia absinthium</i> leaves’ essential oils, extracted via the hydro distillation method along with evaluation of their antioxidant as well as antimicrobial effects. The constituents of EOs were identified using a combined gas chromatography-mass spectrometric (GC-MS) technique. A total of 25 compounds in <i>A. scoparia</i> essential oil (EOAS) were identified, and 14 compounds with percentage abundance of >1% were tabulated, the major being tocopherol derivatives (47.55%). A total of nine compounds in <i>Artemisia absinthium</i> essential oil (EOAA) were enlisted (% age > 1%), the majority being oleic acid derivatives (41.45%). Strong antioxidant effects were pronounced by the EOAS in DPPH (IC₅₀ = 285 ± 0.82 µg/mL) and in ABTS (IC₅₀ = 295 ± 0.32 µg/mL) free radical scavenging assays. Both the EOs remained potent in inhibiting the growth of bacterial species; <i>Escherichia coli</i> (55–70%) and <i>Shigella flexneri</i> (60–75%) however remained moderately effective against <i>Bacillus subtilis</i> as well as <i>Staphylococcus aureus</i>. Both EOAS and EOAA strongly inhibited the growth of the tested fungal species, especially <i>Aspergillus</i> species (up to 70%). The oils showed anti-cholinesterase potential by inhibiting both Acetylcholinesterase (AChE; IC₅₀ = 30 ± 0.04 µg/mL (EOAS), 32 ± 0.05 µg/mL (EOAA) and Butyrylcholinesterase (BChE; IC₅₀ = 34 ± 0.07 µg/mL (EOAS), 36 ± 0.03 µg/mL (EOAA). In conclusion, the essential oils of <i>A. scoparia</i> and <i>A. absinthium</i> are promising antioxidant, antimicrobial and anticholinergic agents with a different phytochemical composition herein reported for the first time.