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<p><strong>Objective</strong> To investigate the morbidity and associated factors of early onset depression after acute ischemic stroke, in order to improve its diagnostic rate and cure rate.  <strong>Methods</strong> The depression symptoms of 150 patients with acute ischemic stroke were evaluated by using Hamilton Depression Rating Scale-17 (HAMD-17) 2 weeks after onset. According to Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-Ⅳ) criteria, patients with HAMD-17 score ≥ 7 were diagnosed as post-stroke depression (PSD). Clinical data of those patients, including gender, age, education, laboratory indexes, predisposing factors, National Institute of Health Stroke Scale (NIHSS) score, Trial of Org10172 in Acute Stroke Treatment (TOAST) type, Oxfordshire Community Stroke Project (OCSP) classification, and concurrent carotid artery stenosis were recorded. Univariate and multivariate Logistic regression analysis was used to investigate the related factors of PSD.  <strong>Results</strong> The morbidity of PSD in patients 2 weeks after stroke onset was 18% (27/150). Univariate and multivariate Logistic regression analysis showed triglyceride level (<em>P</em> = 0.042), neural function deficiency (<em>P</em> = 0.001) and concurrent carotid artery stenosis (<em>P</em> = 0.003) were independent risk factors for early onset PSD. Further subgroup analysis indicated concurrent carotid artery stenosis was the independent risk factor for PSD in non-minor stroke patients (<em>P</em> = 0.014). <strong>Conclusions</strong> Stroke patients with severe neurological deficits and carotid artery stenosis are susceptible to early onset PSD.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2015.03.007</p>