Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
oleh: Hung-Wei Cheng, Urs Mörbe, Mechthild Lütge, Céline Engetschwiler, Lucas Onder, Mario Novkovic, Cristina Gil-Cruz, Christian Perez-Shibayama, Thomas Hehlgans, Elke Scandella, Burkhard Ludewig
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
Fibroblastic reticular cells (FRCs) support localisation of immune cells in secondary lymphoid tissues but less is known about the lamina propria. Here the authors use scRNA-seq and intestinal infection to characterise FRCs in the intestinal lamina propria and show specialised niches that foster innate lymphoid cells during homeostasis and infection.