Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
oleh: Wenwen Yue, Liang Chen, Luodan Yu, Bangguo Zhou, Haohao Yin, Weiwei Ren, Chang Liu, Lehang Guo, Yifeng Zhang, Liping Sun, Kun Zhang, Huixiong Xu, Yu Chen
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-05-01 |
Deskripsi
Immunotherapy for the treatment of cancer can be complicated by side effects and poor efficacy. Here, the authors use a nanoparticle-based approach in combination with a TLR7 agonist and sonodynamic therapy, and find that when used together with anti-PD-L1, tumour formation and metastases are impacted.