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Upper gastrointestinal bleeding can be a life threatening complication. Hookworms infestation usually causes chronic blood loss resulting in anemia. A 52 year old male presented to us with massive gastrointestinal blood loss and hemodynamic instability. On examination he had anemia, which on evaluation was iron deficient microcytic hypochromic anemia with eosinophilia. On evaluation of small bowel mucosa showed multiple hookworms moving on the surface. He improved with anthelmintics, blood transfusion and supportive management. The repeat evaluation showed eradication of worms. Hookworms presenting as a massive gastrointestinal bleeding is a rare entity. Enteroscopy plays an important role in diagnosing hookworm infestation.