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Abstract The redox and thermal balances in cancer have been considered two fundamental bases for cancer progression. As a result, the development of novel action ways to disrupt these balances can therefore give potential anticancer benefits. Herein, cinnamaldehyde (CA) as a plant‐derived drug which could accelerate the H2O2 generation and elevate the reactive oxygen species (ROS) level in cancer cells, is employed to elevate the ROS level of cancer cells while the indocyanine green (ICG) as a photothermal agent was co‐delivered to induce oxidative/thermal stress damage to cells that provide a novel but effective way for effective cancer therapy. The CA and ICG were loaded in lipid nanoparticles to be a drug delivery system (DDS) for safe and effective drug delivery to tumour. The HeLa (human cervical cancer cell line) cells were employed as model and showed promising effects both in vitro and in vivo.