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Background: Cashew nut shell liquid contains 90% anacardic acid and 10% cardol. This liquid when comes in contact topically is said to have deleterious effects both orally and systemically. Aim: The present cross-sectional study was conducted to assess the prevalence of oral submucous fibrosis (OSMF) among 600 cashew nut industrial workers in Kanyakumari district. Materials and Methods: Demographic data and tobacco habits were assessed using pretested questionnaire. Ranganathan K clinical grading system was used to examine OSMF. The data were assessed using SPSS version 11.5. Results: The overall prevalence of OSMF among the study population was 0.002%. Conclusion: The observation from this study clearly indicates that safe working environment prevents occupational hazards.