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The aim of this study was to evaluate alterations of plasma hepcidin, cystatin C and gelsolin in ovine theileriosis  (Ghezel  breed). Theileriosis is known as an important challenge in the livestock industry in most parts of the world and Iran. It possesses prominent role in reduction of milk and meat production and can induce widespread lesions in blood and tissues. In this study, after blood sampling from healthy sheep and those   affected by theileriosis, blood parameters such as red blood cells, hematocrit, hemoglobin and white blood cells were determined and those plasma parameters were measured by special kits through Elisa technique. The results suggested significant increase (p