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Background: Visfatin, also known as nicotinamide phosphoribosyltransferase, is an adipokine implicated in obesity and plays an important role in regulating the defense and immune functions and is also suggested as a pro-inflammatory and immunomodulating marker for periodontitis. Hence, the aim of the present study was to assess the salivary levels of visfatin in obese patients with and without chronic periodontitis and nonobese healthy patients. Materials and Methods: A total of 45 patients were divided into: nonobese healthy (Group 1, n = 15, body mass index [BMI] ≤22.9 and waist circumference [WC] <90 for male patients and <80 for female patients, pocket probing depth [PPD] ≤3 mm, gingival index [GI] <1, and clinical attachment level [CAL] = 0), obese without chronic periodontitis (Group 2, n = 15, BMI ≥25.0 and WC ≥90 for male patients and ≥80 for female patients, PPD ≤3 mm, GI <1, and CAL = 0), and obese with chronic periodontitis (Group 3, n = 15, BMI ≥25.0 and WC ≥90 for male participants and ≥80 for female participants, PPD ≥5 mm, GI ≥1, and CAL ≥3 mm). Whole saliva samples were collected, and visfatin levels were evaluated using standard enzyme-linked immunosorbent assay. The results were analyzed using SPSS and Mann–Whitney analysis. Results: The highest visfatin levels from saliva were detected in Group 3, while the lowest levels were detected in Group 1. Significant differences were found in salivary visfatin concentrations among the three groups. Conclusion: The salivary level of visfatin was higher in obese patients with and without chronic periodontitis. Visfatin may be used as an inflammatory marker for the detection of obesity and periodontal disease.