Structural basis for Fullerene geometry in a human endogenous retrovirus capsid
oleh: Oliver Acton, Tim Grant, Giuseppe Nicastro, Neil J. Ball, David C. Goldstone, Laura E. Robertson, Kasim Sader, Andrea Nans, Andres Ramos, Jonathan P. Stoye, Ian A. Taylor, Peter B. Rosenthal
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-12-01 |
Deskripsi
In retroviruses, the capsid protein (CA) forms a shell surrounding the viral core. Here the authors combine cryo-electron microscopy with NMR and X-ray crystallography to examine the CA structure from the human endogenous retrovirus HML2 (HERV-K) and determine the structures of four Fullerene CA closed shells that reveal the molecular basis of capsid assembly.