ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries
oleh: Jan O. Kaufmann, Julia Brangsch, Avan Kader, Jessica Saatz, Dilyana B. Mangarova, Martin Zacharias, Wolfgang E. Kempf, Timm Schwaar, Marco Ponader, Lisa C. Adams, Jana Möckel, Rene M. Botnar, Matthias Taupitz, Lars Mägdefessel, Heike Traub, Bernd Hamm, Michael G. Weller, Marcus R. Makowski
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
New biomarkers are required to improve the assessment of aortic wall integrity and risk of rupture. Here the authors report the development of an imaging probe for ADAMTS4, which they test in an abdominal aortic aneurysm mouse model and show in vivo prediction of aneurysm and rupture.