Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats.
oleh: Jordânia M O Freire, Hellíada V Chaves, Alrieta H Teixeira, Luzia Herminia T de Sousa, Isabela Ribeiro Pinto, José Jackson do N Costa, Nayara Alves de Sousa, Karuza Maria A Pereira, Virgínia C C Girão, Vanessa C S Ferreira, João Evangelista de Ávila Dos Santos, Mary Anne S Lima, Antônia T A Pimenta, Raquel de C Montenegro, Maria Elisabete A de Moraes, Vicente de P T Pinto, Gerardo C Filho, Mirna M Bezerra
| Format: | Article |
|---|---|
| Diterbitkan: | Public Library of Science (PLoS) 2019-01-01 |
Deskripsi
Periodontitis is an immuno-inflammatory disease, which can lead to tooth loss. This study aimed to investigate the efficacy of Platymiscium floribundum Vog., a Brazilian tree which has been used in folk medicine as an anti-inflammatory agent, in a pre-clinical trial of periodontitis in rats. Periodontitis was induced by placing a sterilized nylon (3.0) thread ligature around the cervix of the second left upper molar of the rats, which received (per os) P. floribundum extract (0.1, 1 or 10 mg/kg) or vehicle 1h before periodontitis-challenge and once daily during 11 days. Treatment with P. floribundum (10mg/kg) decreased alveolar bone loss, MPO activity nitrite/nitrate levels, oxidative stress, TNF-α, IL1-β, IL-8/CINC-1, and PGE2 gingival levels, and transcription of TNF-α, IL1-β, COX-2, iNOS, RANK, and RANKL genes, while elevated both BALP serum levels and IL-10 gingival levels. The animals did not show signs of toxicity throughout the experimental course. These findings show that P. floribundum has anti-inflammatory and anti-resorptive properties in a pre-clinical trial of periodontitis, representing an interesting biotechnological tool.