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Localized primary breast amyloidosis is a very rare benign disease characterized by abnormal protein deposition in the mammary glands. Amyloidosis may mimic the appearance of a number of pathologies, both benign and malignant. Clinically, the patient may present with a breast mass or simply with increased breast density and skin thickening. Herein, we report the case of a 45-year-old woman who presented with a breast mass and was ultimately diagnosed with primary breast amyloidosis, and the mass diagnosed with amyloidosis increased in size and there were a greater number of amorphous and irregular microcalcifications on mammography and ultrasound at the 1-year follow-up. To conclude, we presented changes in a case of localized primary breast amyloidosis on mammography and ultrasound images over a period of 1 year. The current standard of care of primary breast amyloidosis is surgical resection; however, the patient should be followed after surgery to monitor the possibility of recurrence of malignancy.