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Changes in tissues and general renin-angiotensin system’s function are    the most important factors in cardiovascular disease such as essential    hypertension. Recent research shows that general  renin - angiotensin     system  affects the short and immediate response , and that of the tissues    systems are effective in long  period functions in controlling cardiovascular    mechanism . This study was carried out to investigat the changes in function    of tissue renin - angiotensin  systems in mesenteric resistance vessels of    Goldblatt tow kidney – one clip ( 2k - 1c ) renovascular hypertensive rats.           Vascular response to angiotensin I and captopril effects were observed    during a period of 2, 4 , 6 and 8 weeks post  hypertension  induction. The    blood pressure of the hypertensive group was measured and compared    with both sham and control groups.           This study showed that after eight weeks of hypertension induction ,    captopril was unable to inhibit converting  angiotensin I to angiotensin II .    These changes were synchronous  with precipitate process of  increased    arterial blood pressure in hypertensive animals.           This was probably due to increased  angiotensin  converting enzyme    activity or production of other enzymes , such as Chymase that , introduced     a role in angiotensin  II  production . More investigation and accurate study    of the process can probably affect to recognize the ethiology  and efficient    treatment of  hypertension and other  cardiovascular disease .