SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory

oleh: Kimiko Shimizu, Yodai Kobayashi, Erika Nakatsuji, Maya Yamazaki, Shigeki Shimba, Kenji Sakimura, Yoshitaka Fukada

Format: Article
Diterbitkan: Nature Portfolio 2016-09-01

Deskripsi

Learning and memory are subject to circadian variation, though the molecular mechanisms behind this are unclear. Here, the authors show SCOP, a regulator of hippocampal memory, undergoes circadian changes in CA1 membrane raft dynamics and contributes to time-dependent changes in long-term memory.