Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues
oleh: Marija Zaric, Pablo D. Becker, Catherine Hervouet, Petya Kalcheva, Andor Doszpoly, Negin Blattman, Lauren A. O’ Neill, Barbara Ibarzo Yus, Clement Cocita, Sung-Yun Kwon, Andrew H. Baker, Graham M. Lord, Linda S. Klavinskis
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-05-01 |
Deskripsi
Mucosal immunisation is important for initiating mucosal CD8+ Tcell responses but mucosal recruitment of protective CD8+ T cells can also be induced by skin immunisation. Here the authors examine the underlying mechanism and report a novel role for ILC1 recruiting CD8+ T cells to the mucosa after skin immunisation.