Comprehensive comparative analysis of prognostic value of serum systemic inflammation biomarkers for colorectal cancer: Results from a large multicenter collaboration
oleh: Hailun Xie, Hailun Xie, Hailun Xie, Guotian Ruan, Guotian Ruan, Guotian Ruan, Lishuang Wei, Heyang Zhang, Heyang Zhang, Heyang Zhang, Yizhong Ge, Yizhong Ge, Yizhong Ge, Qi Zhang, Qi Zhang, Qi Zhang, Mengmeng Song, Mengmeng Song, Mengmeng Song, Xi Zhang, Xi Zhang, Xi Zhang, Xiaoyue Liu, Xiaoyue Liu, Xiaoyue Liu, Shiqi Lin, Shiqi Lin, Shiqi Lin, Ming Yang, Ming Yang, Ming Yang, Chunlei Hu, Chunlei Hu, Chunlei Hu, Meng Tang, Meng Tang, Meng Tang, Li Deng, Li Deng, Li Deng, Wen Hu, Hanping Shi, Hanping Shi, Hanping Shi
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2023-01-01 |
Deskripsi
BackgroundThe incidence of colorectal cancer (CRC) is common and reliable biomarkers are lacking. We aimed to systematically and comprehensively compare the ability of various combinations of serum inflammatory signatures to predict the prognosis of CRC. Moreover, particular attention has been paid to the clinical feasibility of the newly developed inflammatory burden index (IBI) as a prognostic biomarker for CRC.MethodsThe discrimination capacity of the biomarkers was compared using receiver operating characteristic curves and Harrell’s C-index. Kaplan-Meier curves and log-rank tests were used to compare survival differences between the groups. Cox proportional hazard regression analysis was used to determine the independent prognostic factors. Logistic regression analysis was used to assess the relationship between IBI, short-term outcomes, and malnutrition.ResultsIBI had the optimal prediction accuracy among the systemic inflammation biomarkers for predicting the prognosis of CRC. Taking IBI as a reference, none of the remaining systemic inflammation biomarkers showed a gain. Patients with high IBI had significantly worse overall survival than those with low IBI (56.7% vs. 80.2%; log-rank P<0.001). Multivariate Cox regression analysis showed that continuous IBI was an independent risk factor for the prognosis of CRC patients (hazard ratio = 1.165, 95% confidence interval [CI] = 1.043–1.302, P<0.001). High IBI was an independent risk factor for short-term outcomes (odds ratio [OR] = 1.537, 95% CI = 1.258–1.878, P<0.001), malnutrition (OR = 2.996, 95% CI = 1.471–6.103, P=0.003), and recurrence (OR = 1.744, 95% CI = 1.176–2.587, p = 0.006) in CRC patients.ConclusionsIBI, as a reflection of systemic inflammation, is a feasible and promising biomarker for assessing the prognosis of CRC patients.