Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines
oleh: Tri Mayanti, Nur Insani Amir, Dewa Gede Katja, Sofa Fajriah, Ahmad Darmawan, Unang Supratman, Khlaijah Awang, Yoshihito Shiono
| Format: | Article |
|---|---|
| Diterbitkan: | Syarif Hidayatullah Jakarta State Islamic University 2020-12-01 |
Deskripsi
Three steroids, 3α-hydroxystigmast-5(6), 22-diene-7-one (1), stigmasterol (2) and 3-hydroxy-7β-methoxystigmast-5(6)-ene (3), were isolated from the stem bark of Dysoxylum nutans. The chemical structures were identified by spectroscopic data, which includes IR, 1D-NMR, 2D-NMR, and HR-TOFMS as well as by comparing previously reported spectral data. Compounds 1-3 were tested for cytotoxic effect against MCF-7 breast cancer cell lines and compound 1 showed the strongest cytotoxic activity with an IC50 value of 20.13 ± 0.06 μM.