Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction
oleh: Feng Gao, Masaharu Kataoka, Ning Liu, Tian Liang, Zhan-Peng Huang, Fei Gu, Jian Ding, Jianming Liu, Feng Zhang, Qing Ma, Yingchao Wang, Mingming Zhang, Xiaoyun Hu, Jan Kyselovic, Xinyang Hu, William T. Pu, Jian’an Wang, Jinghai Chen, Da-Zhi Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
The miR-17-92 cluster has been shown to regulate cardiomyocyte proliferation in vitro and in genetic mutation and overexpression models. Here the authors show that the cluster member miR-19a/19b regulates cardiomyocyte proliferation in vivo, and that delivery of miR-19a/19b to the heart leads to both short-term and long-term protective responses to myocardial infarction.