Use of activated enol ethers in the synthesis of pyrazoles: reactions with hydrazine and a study of pyrazole tautomerism
oleh: Denisa Tarabová, Stanislava Šoralová, Martin Breza, Marek Fronc, Wolfgang Holzer, Viktor Milata
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2014-04-01 |
Deskripsi
Activated enol ethers derived from esters or the dinitrile of malonic acid, or from pentane-2,4-dione were treated with hydrazine hydrate. The structures of the obtained products – pyrazoles 5 – were studied with a focus on tautomerism and supramolecular structure. A reverse addition of the reagents led to the isolation of two novel products, namely bis-enehydrazines 6 with an unsymmetrical arrangement of the formally equivalent subunits.