Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site
oleh: Yu-Chen Lo, Olga Cormier, Tianyun Liu, Kendall W. Nettles, John A. Katzenellenbogen, Tim Stearns, Russ B. Altman
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-03-01 |
Deskripsi
Taxanes are natural products which bind beta-tubulin, stabilize microtubules and have a broad spectrum of anticancer activity. Here authors employ a computational binding site similarity screen and cell-based assays to reveal a SERM cross-reactivity between the estrogen receptor and the beta-tubulin taxane binding pocket.