IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis
oleh: Chiara Cioccarelli, Chiara Cioccarelli, Ricardo Sánchez-Rodríguez, Ricardo Sánchez-Rodríguez, Roberta Angioni, Roberta Angioni, Francisca C. Venegas, Francisca C. Venegas, Nicole Bertoldi, Nicole Bertoldi, Fabio Munari, Fabio Munari, Annamaria Cattelan, Barbara Molon, Barbara Molon, Antonella Viola, Antonella Viola
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2021-12-01 |
Deskripsi
After the outburst of the SARS-CoV-2 pandemic, a worldwide research effort has led to the uncovering of many aspects of the COVID-19, among which we can count the outstanding role played by inflammatory cytokine milieu in the disease progression. Despite that, molecular mechanisms that regulate SARS-CoV-2 pathogenesis are still almost unidentified. In this study, we investigated whether the pro-inflammatory milieu of the host affects the susceptibility of SARS-CoV-2 infection by modulating ACE2 and TMPRSS2 expression. Our results indicated that the host inflammatory milieu favors SARS-CoV-2 infection by directly increasing TMPRSS2 expression. We unveiled the molecular mechanism that regulates this process and that can be therapeutically advantageously targeted.