NOTCH1 is a mechanosensor in adult arteries
oleh: Julia J. Mack, Thiago S. Mosqueiro, Brian J. Archer, William M. Jones, Hannah Sunshine, Guido C. Faas, Anais Briot, Raquel L. Aragón, Trent Su, Milagros C. Romay, Austin I. McDonald, Cheng-Hsiang Kuo, Carlos O. Lizama, Timothy F. Lane, Ann C. Zovein, Yun Fang, Elizabeth J. Tarling, Thomas Q. de Aguiar Vallim, Mohamad Navab, Alan M. Fogelman, Louis S. Bouchard, M. Luisa Iruela-Arispe
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-11-01 |
Deskripsi
The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.