Asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-β-keto esters
oleh: Lin Yan, Zhiqiang Han, Bo Zhu, Caiyun Yang, Choon-Hong Tan, Zhiyong Jiang
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2013-09-01 |
Deskripsi
In the presence of a commercially available Cinchona alkaloid as catalyst, the asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates, with α-fluoro-β-keto esters as nucleophiles, have been successfully developed. A series of important fluorinated adducts, with chiral quaternary carbon centres containing a fluorine atom, was achieved in good yields (up to 93%), with good to excellent enantioselectivities (up to 96% ee) and moderate diastereoselectivities (up to 4:1 dr).