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The Lunnan oilfield, nestled within the Tarim Basin, represents a prototypical extra-low-permeability sandstone reservoir, distinguished by high-quality crude oil characterised by a low viscosity, density, and gel content. The effective exploitation of such reservoirs hinges on the implementation of carbon dioxide (CO₂) flooding techniques. This study, focusing on the sandstone reservoirs of Lunnan, delves into the mechanisms of CO₂-assisted oil displacement under diverse operational parameters: injection pressures, CO₂ concentration levels, and variations in crude oil properties. It integrates analyses on the high-pressure, high-temperature behaviour of CO₂, the dynamics of CO₂ injection and expansion, prolonged core flood characteristics, and the governing principles of minimum miscible pressure transitions. The findings reveal a nuanced interplay between variables: CO₂’s density and viscosity initially surge with escalating injection pressures before stabilising, whereas they experience a gradual decline with increasing temperature. Enhanced CO₂ injection correlates with a heightened expansion coefficient, yet the density increment of degassed crude oil remains marginal. Notably, CO₂ viscosity undergoes a substantial reduction under stratigraphic pressures. The sequential application of water alternating gas (WAG) followed by continuous CO₂ flooding attains oil recovery efficiency surpassing 90%, emphasising the superiority of uninterrupted CO₂ injection over processes lacking profiling. The presence of non-miscible hydrocarbon gases in segmented plug drives impedes the oil displacement efficiency, underscoring the importance of CO₂ purity in the displacement medium. Furthermore, a marked trend emerges in crude oil recovery rates as the replacement pressure escalates, exhibiting an initial rapid enhancement succeeded by a gradual rise. Collectively, these insights offer a robust theoretical foundation endorsing the deployment of CO₂ flooding strategies for enhancing oil recovery from sandstone reservoirs, thereby contributing valuable data to the advancement of enhanced oil recovery (EOR) technologies in challenging, low-permeability environments.