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It is well known that among the materials used in the daily lives of individuals and also in industrial applications, the specific structures applied in biomedicine occupy a special place. It is connected with the possibility to expand our basic physical-chemical knowledge and regarded to the real application of novel structures in the interdisciplinary arena. In this paper, a comparative study is conducted on the influence of different materials: sugar, DNA, WS₂ nanoparticles, dyes—on the rotation of the plane of polarization of light. Firstly, this effect is shown namely for a liquid crystal mixture doped with WS₂ nanotubes. On the one hand, it is shown that the new materials are quite suitable for use in sugar-meters and polarimeter devices instead of sugar solutions. On the other hand, the rotation of the plane of polarization of light in solutions with DNA and WS₂ nanoparticles in water or in the liquid crystal mixture can predict a larger angle of the rotation of the polarization plane of the light and can find a better design than in volumetric classical sugar solutions. This makes it possible to expand the application of these materials to the technical devices.