MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
oleh: Qin Yu, Alba Herrero del Valle, Rahul Singh, Yorgo Modis
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-11-01 |
Deskripsi
MDA5 is the primary immune sensor for SARS-CoV-2 and many other viruses. Mutations in MDA5 can cause disease. Here the authors employ CryoEM and biochemical methods to show how steric constraints cause MDA5 to misrecognize endogenous RNA as viral RNA.