Find in Library

Five new chromone-derived polyketides phaseolorins A-F (<b>1</b>&#8211;<b>5</b>), together with nine known compounds, were isolated from the deep-sea derived fungus <i>Diaporthe phaseolorum</i> FS431. The structures of new compounds were determined by analysis of their NMR and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectroscopic data. The absolute configurations were confirmed by chemical transformations, extensively experimental electron capture detection (ECD) calculations, or X-ray crystallography. Among them, compound <b>2</b> represented the first example for a new family of chromone derivative possessing an unprecedented recombined five-member <i>&#947;</i>-lactone ring. Moreover, the new compounds (<b>1</b>&#8211;<b>5</b>) were evaluated for in vitro cytotoxic activities against a panel of human cancer cell lines.