Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division
oleh: Sylvain Loubéry, Alicia Daeden, Carole Seum, Laurent Holtzer, Ana Moraleda, Nicolas Damond, Emmanuel Derivery, Thomas Schmidt, Marcos Gonzalez-Gaitan
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-06-01 |
Deskripsi
Asymmetric segregation of cell fate determinants during cell division governs daughter cell fate. Here the authors show that Sara endosomes, known to regulate Notch signalling, are targeted to the mitotic spindle and once phosphorylated are asymmetrically dispatched into a daughter cell to determine cell fate.