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The research group for analytical and bioanalytical sciences at the Department of Chemistry of the University of Basel is working on miniaturization of analytical techniques, with special focus on detection. Downsizing is a challenge for quantitation and contributions have been made based on different techniques which encompass atomic and molecular spectroscopy as well as different electroanalytical methods. Particularly successful has been contactless conductivity detection and an introduction to this technique is given as an example of the activities of the research group.