Find in Library

A novel compound (<b>1</b>) along with two known compounds (<b>2</b> and <b>3</b>) were isolated from the culture broth of <i>Chlorophyllum molybdites</i>, and three known compounds (<b>4</b>–<b>6</b>) were isolated from its fruiting bodies. The planar structure of <b>1</b> was determined by the interpretation of spectroscopic data. By comparing the specific rotation of the compound with that of the analog compound, the absolute configuration of <b>1</b> was determined to be <i>R</i>. This is the first time that compounds <b>2</b>–<b>4</b> were isolated from a mushroom-forming fungus. Compound <b>2</b> showed significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2). In the bioassay to examine growth inhibitory activity against the phytopathogenic bacteria <i>Peptobacterium carotovorum</i>, <i>Clavibacter michiganensis</i> and <i>Burkholderia glumae</i>, compounds <b>2</b> and <b>3</b> inhibited the growth of <i>P. carotovorum</i> and <i>C. michiganensis.</i> In the bioassay to examine plant growth regulatory activity, compounds <b>1</b>–<b>4</b> showed a significant regulatory activity on lettuce growth.