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The Autumn Meeting of the British Society for Cardiovascular Research in 2021 was a virtual meeting organised by Andrew Bond, Anita Thomas, Elisa Avolio, Michele Carrabba, Raimondo Ascione, and Paolo Madeddu of the Bristol Medical School. The theme of the meeting was ‘Tissue engineering and regenerative medicine in cardiovascular disease’ and included an early career symposium. The Annual Bernard and Joan Marshall Distinguished Investigator Lecture was given by Professor Toshiharu Shinoka. This paper presents the abstracts selected for oral and poster presentations.