Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals
oleh: Satvinder Kaur, Roberto De Luca, Mudasir A. Khanday, Sathyajit S. Bandaru, Renner C. Thomas, Rebecca Y. Broadhurst, Anne Venner, William D. Todd, Patrick M. Fuller, Elda Arrigoni, Clifford B. Saper
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2020-06-01 |
Deskripsi
Dorsal raphe 5HT(DRSert) neurons regulate arousal from hypercapnia by their projections to the neurons in the external lateral parabrachial nucleus (PBel) that are glutamatergic and also express calcitonin gene related peptide (PBelCGRP). The DRSert input to the PBel modulates the arousal system to rising levels of blood CO2, and may be mediated by 5HT2a receptors on the PBelCGRP neurons.