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The aim of this study is to evaluate the efficiency of protocatechuic acid (PCA) in enhancing the commonly used drugs used to fight against nosocomial infection. These drugs are represented by routinely used antibiotics, synthetic chemotherapeutic agents with an antimicrobial spectrum, and antifungals. Three concentrations of PCA were added to 12 types of commercial disks used for antibiotic and antifungal susceptibility and tested against bacterial and yeast strains represented by <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i>. The results proved that PCA increased up to 50% of the antibacterial activity, especially that of levofloxacin against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. These formulations will lead to new drug design ideas containing a smaller amount of antibiotics with the same effectiveness.