A <i>Saccharomyces cerevisiae</i> model and screen to define the functional consequences of oncogenic histone missense mutations
oleh: Laramie D Lemon, Sneha Kannan, Kim Wai Mo, Miranda Adams, Haley G Choi, Alexander O D Gulka, Elise S Withers, Hasset T Nurelegne, Valeria Gomez, Reina E Ambrocio, Rhea Tumminkatti, Richard S Lee, Morris Wan, Milo B Fasken, Jennifer M Spangle, Anita H Corbett
| Format: | Article |
|---|---|
| Diterbitkan: | Oxford University Press 2022-05-01 |
Deskripsi
AbstractSomatic missense mutations in histone genes turn these essential proteins into oncohistones, which can drive oncogenesis. Understanding how missense mutations alter histone function is challenging in mammals as mutations occur in a single histone gene. For example, described oncohistone mutations predominantly occur in the histone H3.3