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Abstract We extend recent discussions of singularity avoidance in quantum gravity from isotropic to anisotropic cosmological models. The investigation is done in the framework of quantum geometrodynamics (Wheeler–DeWitt equation). We formulate criteria of singularity avoidance for general Bianchi class A models and give explicit and detailed results for Bianchi I models with and without matter. The singularities in these cases are big bang and big rip. We find that the classical singularities can generally be avoided in these models.