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Objective: The aim of the present study was to calculate the mean differences in serum sodium and potassium concentration levels in  patients  with  Benign  Prostatic  Hyperplasia  undergoing  TURP  pre  and post-operation. Methods: A cross-sectional and observational study was conducted at the  Department  of  Urology,  Liaquat National Medical College and Hospital, Karachi, Pakistan. Purposive, convenience sampling technique was used. A total of 75  male  patients  undergoing  transurethral  resection  of  the  prostate  were included in the study. Data was analysed using SPSS version 20.0. A p-value of less than 0.05 was considered to be significant. Results: Out of a total of seventy-five patients, the mean age was 59.59 ± 7.02 years. After surgery,      1.3% (1) patient had hyponatremia (<135 mmol/L), 97.3% (73) patients had normal sodium level (135-145 mmol/L) and 1.3% (1) patient had hypernatremia (>145 mmol/L). In contrast, only 1 (1.3%)  patient had hypokalaemia, 66.7% (50) patients  had  normal  potassium  levels  and  32%  (24)  patients  had hyperkalaemia (p-value 0.001). Conclusion: We reported a significant increase in serum levels  of  potassium  in  post-surgery  evaluation. Therefore, the monitoring of  serum  electrolyte  concentration  following  transurethral  resection  of  the prostate (TURP) is highly recommended.