iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer
oleh: Naiqing Ding, Zhengyun Zou, Huizi Sha, Shu Su, Hanqing Qian, Fanyan Meng, Fangjun Chen, Shiyao Du, Shujuan Zhou, Hong Chen, Lianru Zhang, Ju Yang, Jia Wei, Baorui Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-03-01 |
Deskripsi
The therapeutic efficacy of adoptive T cell transfer is limited by their ability to infiltrate solid tumours. Here, the authors show that loading the tumor penetrating cyclic peptide iRGD on the cell surface of T cells enhances their ability to penetrate the tumour, resulting in enhanced efficacy in a mouse model of gastric cancer.